{"created":"2023-05-15T14:58:45.215677+00:00","id":87,"links":{},"metadata":{"_buckets":{"deposit":"989723c2-ea39-465d-8d76-f033aa403c3c"},"_deposit":{"created_by":10,"id":"87","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"87"},"status":"published"},"_oai":{"id":"oai:meiji-u.repo.nii.ac.jp:00000087","sets":["2:11"]},"author_link":["201"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-02-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"42","bibliographicPageStart":"33","bibliographic_titles":[{"bibliographic_title":"明治国際医療大学誌"},{"bibliographic_title":"The Bulletin of Meiji University of Integrative Medicine","bibliographic_titleLang":"en"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景・目的】難治性の慢性疼痛の中でも,特に神経因性に発症する痛みに対しては有効な治療方法が確立されていない.近年,神経因性疼痛は脊髄レベルの研究が進展する一方で,脳内における痛み認知にも目が向けられ始めている.今回,脊髄神経結紮(segmental spinal nerve ligation;SNL)モデルを用い,触刺激による痛み誘発時の脳賦活を,神経賦活磁気共鳴画像法(activity-induced manganese-enhanced MRI;AIM MRI)にて検出することを目的とした.【対象・方法】雄性Sprague-Dawleyラット(n=14)をSNL群(n=9)とsham群(n=5)に分けた.SNL群は第5,第6脊髄神経を結紮し,慢性疼痛モデルを作成した.モデル作成後1〜2週間後にAIM MRIを実施し,脳賦活画像を取得した.【結果・考察】触刺激による痛みの誘発によって,第2次体性感覚野および大脳基底核とその周囲に有意な信号上昇が観察された.AIM MRIによって,慢性疼痛発症時の脳賦活を検出できた.(著者抄録)","subitem_description_type":"Abstract"}]},"item_10004_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1884-1414","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河合, 裕子"},{"creatorName":"カワイ, ユウコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawai, Yuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"201","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-03"}],"displaytype":"detail","filename":"04_kawai.pdf","filesize":[{"value":"700.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"04_kawai","url":"https://meiji-u.repo.nii.ac.jp/record/87/files/04_kawai.pdf"},"version_id":"0fc3b043-ce1f-412f-a890-c5cdf557a8ba"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"慢性疼痛","subitem_subject_scheme":"Other"},{"subitem_subject":"神経因性疼痛","subitem_subject_scheme":"Other"},{"subitem_subject":"アロディニア","subitem_subject_scheme":"Other"},{"subitem_subject":"脊髄神経 結紮モデル","subitem_subject_scheme":"Other"},{"subitem_subject":"神経賦活磁気共鳴画像法","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neuropathic pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"allodynia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SNL model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"AIM MRI","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"慢性疼痛発症モデルラットにおけるActivity-induced Manganese-enhanced MRIを用いた脳賦活の検出","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"慢性疼痛発症モデルラットにおけるActivity-induced Manganese-enhanced MRIを用いた脳賦活の検出"},{"subitem_title":"Detection of Brain Activity during Chronic Pain Using Activity-Induced  Manganese-Enhanced MRI in the Rat","subitem_title_language":"en"}]},"item_type_id":"10004","owner":"10","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-03"},"publish_date":"2022-03-03","publish_status":"0","recid":"87","relation_version_is_last":true,"title":["慢性疼痛発症モデルラットにおけるActivity-induced Manganese-enhanced MRIを用いた脳賦活の検出"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-05-15T15:50:50.204086+00:00"}