{"created":"2023-05-15T14:58:56.472791+00:00","id":275,"links":{},"metadata":{"_buckets":{"deposit":"c0909a66-8af3-4fe9-b4c7-4809ed1c3ec1"},"_deposit":{"created_by":10,"id":"275","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"275"},"status":"published"},"_oai":{"id":"oai:meiji-u.repo.nii.ac.jp:00000275","sets":["2:33"]},"author_link":["744","740","743"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-12-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"13","bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"明治国際医療大学誌"},{"bibliographic_title":"The Bulletin of Meiji University of Integrative Medicine","bibliographic_titleLang":"en"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アレルギー反応の成立には局所における2型ヘルパーT細胞(Th2)とマクロファージ(Mp)との相互作用が必須であり,Mpの細胞内還元型グルタチオン(icGSH)濃度を上昇させることでTh2応答を抑制できる.icGSH濃度を有効に上昇させるN-アセチルシステイン(NAC)点眼を用いたアレルギー性結膜炎治療効果を検討した.季節性アレルギー性結膜炎患者30例に対し,片眼にNAC(30mg/ml),もう片眼に2%クロモグリク酸ナトリウム(SCG)をそれぞれ1日4回,14日点眼させた.自覚症状(眼そう痒感・流涙・羞明・眼脂・眼痛・異物感)をアレルギー日記作製により7段階にスコア化し,他覚所見とともに比較検討した.また,点眼前後の結膜上皮を採取し,icGSH量変化を比較した.結果,NAC点眼液によって有意なicGSH量増加が見られた.NAC治療眼ではSCG治療眼と同等にそう痒感,流涙,眼脂,眼痛,異物感が点眼前より有意に改善し,そう痒感と流涙においては点眼14日後でSCG治療眼よりも有意な改善が見られた(p<0.05).NAC点眼は抗アレルギー作用を有しており,icGSH上昇といった新たな機序を介する抗アレルギー薬の開発が期待できた.(著者抄録)","subitem_description_type":"Abstract"}]},"item_10004_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1884-1414","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"堀内, 稔子"},{"creatorName":"ホリウチ, ノリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Horiuchi, Noriko ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"740","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 潤"},{"creatorName":"ヤマダ, ジュン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"743","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Jun","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"744","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-09"}],"displaytype":"detail","filename":"01_horiuchi.pdf","filesize":[{"value":"805.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"01_horiuchi","url":"https://meiji-u.repo.nii.ac.jp/record/275/files/01_horiuchi.pdf"},"version_id":"306cbb77-b5b9-47a5-8c5f-d9183c80fc27"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"N アセチルシステイン","subitem_subject_scheme":"Other"},{"subitem_subject":"アレルギー性結膜炎","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞内チオールレドックス","subitem_subject_scheme":"Other"},{"subitem_subject":"N-acetyl cysteine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"allergic conjunctivitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intracellular glutathione contents","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"N-アセチルシステイン点眼によるアレルギー性結膜炎抑制効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"N-アセチルシステイン点眼によるアレルギー性結膜炎抑制効果"},{"subitem_title":"The efficacy of N-acetyl cysteine for the treatment  of allergic conjunctivitis","subitem_title_language":"en"}]},"item_type_id":"10004","owner":"10","path":["33"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-09"},"publish_date":"2022-03-09","publish_status":"0","recid":"275","relation_version_is_last":true,"title":["N-アセチルシステイン点眼によるアレルギー性結膜炎抑制効果"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-05-15T15:12:15.375286+00:00"}