{"created":"2023-05-15T14:58:41.835688+00:00","id":14,"links":{},"metadata":{"_buckets":{"deposit":"4bc0eb12-5f58-4c91-aa52-393a27a05b80"},"_deposit":{"created_by":10,"id":"14","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"14"},"status":"published"},"_oai":{"id":"oai:meiji-u.repo.nii.ac.jp:00000014","sets":["1:9","2:37"]},"author_link":["13","22","12","25","16","18","28","26","14","27","15"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-17"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"明治国際医療大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博 士（鍼灸学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2016年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】本研究は，低頻度と高頻度の鍼通電刺激（以下，低頻度刺激，高頻度刺激と称す）がラット下腿筋群の筋血流量に及ぼす影響と，これらの作用機序における ATP と ADPの関与について検討した．\n【方法】実験動物には Sprague-Dawley 系ラット（雄，N＝133）を用いた．低頻度刺激（2Hz）または高頻度刺激（100Hz）を右前脛骨筋に 5 分間与えた．下腿筋群の筋血流量測定には蛍光マイクロスフェアを，前脛骨筋の透析液の回収にはマイクロダイアリシス法を，透析液中の ATP，ADP，AMP，アデノシンの解析には高速液体クロマトグラフィを用いた．P2 受容体拮抗薬としてスラミン（100mg/kg）を用いた．\n【結果】低頻度及び高頻度刺激は刺激中の筋血流量を有意に増加させたが，両刺激の間に有意差は認められなかった．刺激後 30 分において，低頻度刺激は ATP と ADP の合計濃度を，高頻度刺激はアデノシンを有意に増加した．P2 受容体拮抗薬は刺激後 30 分における低頻度刺激による筋血流量を有意に抑制したが，高頻度刺激では認められなかった．\n【考察および結語】低頻度と高頻度刺激による筋血流量増加の作用機序は異なること，また，低頻度刺激による刺激後の筋血流量の増加に ATP と ADP が限定的に関与することが示唆された．","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"34318鍼博甲第72号"}]},"item_10006_publisher_5":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"明治国際医療大学附属図書館"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"明治国際医療大学誌"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"第16号"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"1-12"}]}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長岡, 里美"},{"creatorName":"ナガオカ, サトミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"18","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"新原, 寿志"},{"creatorName":"シンバラ, ヒサシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"12","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 啓作"},{"creatorName":"キムラ, ケイサク","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河北, 剛"},{"creatorName":"カワキタ, ツヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawakita, Tsuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"日野, こころ"},{"creatorName":"ヒノ, ココロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"26","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"角谷, 英治"},{"creatorName":"スミヤ, エイジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagaoka, Satomi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinbara, Hisashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Keisaku","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hino, Kokoro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"28","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sumiya, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-22"}],"displaytype":"detail","filename":"01_nagaoka.pdf","filesize":[{"value":"951.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"01_nagaoka","url":"https://meiji-u.repo.nii.ac.jp/record/14/files/01_nagaoka.pdf"},"version_id":"9bf722c0-948d-4147-9649-c56dacaab0c5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"高頻度鍼通電刺激","subitem_subject_scheme":"Other"},{"subitem_subject":"低頻度鍼通電刺激","subitem_subject_scheme":"Other"},{"subitem_subject":"骨格筋血流","subitem_subject_scheme":"Other"},{"subitem_subject":"ATP","subitem_subject_scheme":"Other"},{"subitem_subject":"ADP","subitem_subject_scheme":"Other"},{"subitem_subject":"high EA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"low EA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"skeletal muscle  blood flow","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ATP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ADP","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"鍼通電刺激がラット下腿筋群の筋血流量に及ぼす影響 ―低頻度および高頻度鍼通電刺激の相違と ATP および ADP の関与―","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"鍼通電刺激がラット下腿筋群の筋血流量に及ぼす影響 ―低頻度および高頻度鍼通電刺激の相違と ATP および ADP の関与―"},{"subitem_title":"Effects of electroacupuncture stimulation on  skeletal muscle blood flow in the rat hindlimb","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"10","path":["9","37"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-22"},"publish_date":"2022-02-22","publish_status":"0","recid":"14","relation_version_is_last":true,"title":["鍼通電刺激がラット下腿筋群の筋血流量に及ぼす影響 ―低頻度および高頻度鍼通電刺激の相違と ATP および ADP の関与―"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-05-15T15:01:21.962071+00:00"}